Uzramma has been involved for over twenty-five years in issues connected with the growing, spinning, and weaving of cotton, advocating small-scale, dispersed, and diverse production chains that can be owned and managed by producers themselves. She has worked with cotton handloom weaver cooperatives in Andhra Pradesh and Telangana states, helping to set up systems of management and marketing. Among the NGOs founded by her are the Dastkar Andhra Trust, the Decentralised Cotton Yarn Trust, and the Malkha Trust. She is also a co-founder of the Handloom Futures Trust.